ADAM15

Across TCGA patient cohorts, ADAM15 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM15-associated genes across cancer lineages are ATM, MEK1, and Caspase-8. Each is linked with ADAM15 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM15-to-partner and partner-to-ADAM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADAM15-low versus ADAM15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM15→partner) and Y-score (partner→ADAM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.559	-3.169	.002	.019	3	3
UCEC	MEK1 →	+0.337	+2.584	.025	.010	3	2
UCEC	Caspase-8 →	-0.268	-3.807	.009	<.001	3	2
UCEC	Cyclin-B1 →	+0.739	+2.584	.001	.010	3	2
SKCM	p21 →	-0.500	-3.152	.033	.019	3	1
UCEC	eEF2 →	+0.340	+2.999	.021	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by ADAM15 expression — UCEC

Explore this box plot interactively →