ADAM15

Across TCGA pan-cancer cohorts, ADAM15 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ADAM15 data layer compared with 8 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ADAM15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADAM15 expression acts as an unfavorable survival marker, although some lineages such as STAD and THCA show a favorable association.

KIRP, UVM, and BRCA are the cancer types where ADAM15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.777	0.931	<.001	149	view →
UVM	DFS	Median	All	0.430	0.754	<.001	105	view →
BRCA	DFS	Median	All	0.930	0.967	<.001	88	view →
LIHC	OS	Median	All	0.451	0.691	<.001	57	view →
LGG	DFS	Median	All	0.276	0.490	<.001	54	view →
UCS	DFS	Median	II,III,IV	0.261	0.596	.003	42	view →
LAML	DFS	Tertile	All	0.214	0.537	.001	32	view →
KICH	DFS	Tertile	All	0.688	1.000	.022	21	view →
READ	OS	Tertile	IV	0.378	0.814	.009	18	view →
MESO	OS	Tertile	II,III,IV	0.228	0.692	.006	18	view →
ACC	DFS	Tertile	II,III,IV	0.216	0.572	.008	13	view →
PAAD	DFS	Quartile	All	0.251	0.565	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ADAM15–KIRP (DFS)

Open the KIRP breakdown →