ADAM15

Across TCGA pan-cancer cohorts, ADAM15 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ADAM15’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ADAM15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM15 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, KIRC, and LIHC are the cancer types where ADAM15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.023	<.001	11	view →
KIRC	Female	All	+0.823	<.001	11	view →
LIHC	Male	All	+1.823	<.001	9	view →
LUAD	Female	III,IV	+1.221	<.001	9	view →
THCA	Male	All	+0.581	<.001	9	view →
KIRP	All	II,III,IV	+0.969	.002	7	view →
KICH	Female	All	−1.582	<.001	6	view →
STAD	Male	II,III,IV	+0.869	<.001	6	view →
BLCA	All	III,IV	+0.746	.006	6	view →
BRCA	All	III,IV	+0.697	<.001	6	view →
CHOL	Female	All	+3.050	<.001	5	view →
LUSC	All	All	+0.355	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ADAM15–COAD

Open the COAD breakdown →