ADAM15

Across TCGA cell cohorts, ADAM15 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM15-associated genes across cancer lineages are GFRA4, OTOP1, and TBPL2. Each is linked with ADAM15 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM15-to-partner and partner-to-ADAM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by ADAM15-low versus ADAM15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM15→partner) and Y-score (partner→ADAM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.019	+3.345	.001	.007	3	2
LUNG_NSCLC_LUAD	OTOP1 →	+0.011	+3.215	.003	.007	3	2
BLOOD_Leukemia	TBPL2 →	+0.055	+3.090	.001	.001	3	2
BLOOD_Leukemia	ACTN3 →	+0.061	+2.989	.001	.002	3	2
LARGE_INTESTINE	TKTL2 →	+0.050	+4.187	<.001	.002	3	1
LARGE_INTESTINE	TREML1 →	+0.114	+3.658	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

GFRA4 by ADAM15 expression — LARGE_INTESTINE

Explore this box plot interactively →