ADAM15

Across TCGA cell cohorts, ADAM15 mutation is significantly associated with the mutation status of many other genes, with 3,802 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM15-associated genes across cancer lineages are COPB1, LIMK1, and PRUNE2. Each is linked with ADAM15 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAM15-to-partner and partner-to-ADAM15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPB1 grouped by ADAM15-low versus ADAM15-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM15→partner) and Y-score (partner→ADAM15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COPB1 →	+3.772	+3.772	.003	.003	1	4
BLOOD_Leukemia	LIMK1 →	+4.794	+3.309	.002	.002	1	4
LUNG_NSCLC_LUAD	PRUNE2 →	+2.133	+4.022	.002	.002	1	4
LUNG_NSCLC_LUAD	F8 →	+2.981	+3.266	.009	.009	1	4
SKIN	CYFIP1 →	+3.357	+3.532	.005	.005	1	4
SKIN	DGKQ →	+3.772	+3.772	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,802 associations by consensus.

COPB1 by ADAM15 expression — SKIN

Explore this box plot interactively →