ACY3

Across TCGA patient cohorts, ACY3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACY3-associated genes across cancer lineages are c-Met_pY1235, FASN, and ATM. Each is linked with ACY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACY3-to-partner and partner-to-ACY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by ACY3-low versus ACY3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACY3→partner) and Y-score (partner→ACY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.093	+3.009	.012	.019	3	2
UCEC	FASN →	+0.476	+3.000	.016	.036	2	2
UCEC	ATM →	-0.603	-2.321	.008	.035	3	1
UCEC	4E-BP1 →	+0.449	+2.321	<.001	.035	3	1
UCEC	ACC1 →	+0.529	+2.321	.003	.035	2	1
UCEC	p62 Lck ligand →	+0.582	+3.009	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

c-Met_pY1235 by ACY3 expression — UCEC

Explore this box plot interactively →