ACY3

Across TCGA pan-cancer cohorts, ACY3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ACY3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ACY3 RNA is repressed in tumor relative to normal tissue. In most cancer types ACY3 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and LUAD are the cancer types where ACY3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACY3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−5.733	<.001	11	view →
KIRP	All	III,IV	−2.985	<.001	10	view →
LUAD	Male	II,III,IV	+1.730	<.001	9	view →
HNSC	Male	All	+0.877	<.001	7	view →
COAD	Male	II,III,IV	+0.732	.007	6	view →
BRCA	Female	All	−0.426	.011	6	view →
CHOL	All	All	−1.757	<.001	3	view →
UCEC	All	All	+1.013	.019	2	view →
KIRC	All	II,III,IV	+0.817	.013	2	view →
PRAD	All	All	−0.557	.001	2	view →
LUSC	All	All	+0.315	.015	2	view →
LIHC	Female	All	−0.968	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ACY3–KICH

Open the KICH breakdown →