ACY3

Across TCGA pan-cancer cohorts, ACY3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ACY3 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ACY3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ACY3 expression acts as an unfavorable survival marker, although some lineages such as KIRP and SKCM show a favorable association.

KIRP, SKCM, and KIRC are the cancer types where ACY3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	All	0.892	0.658	<.001	141	view →
SKCM	DFS	Median	All	0.680	0.556	<.001	131	view →
KIRC	DFS	Tertile	All	0.738	0.530	<.001	112	view →
BLCA	OS	Tertile	IV	0.715	0.483	.003	86	view →
UCEC	DFS	Median	III,IV	0.749	0.408	<.001	76	view →
UVM	DFS	Median	All	0.429	0.761	.001	62	view →
OV	OS	Median	III,IV	0.367	0.269	.003	52	view →
READ	DFS	Tertile	All	0.949	0.423	.007	20	view →
LAML	DFS	Quartile	All	0.270	0.568	.004	16	view →
SCLC	DFS	Tertile	All	0.943	0.435	.006	14	view →
ESCA	OS	Median	All	0.617	1.000	.009	13	view →
LUSC	OS	Tertile	IV	0.081	1.000	.038	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ACY3–KIRP (OS)

Open the KIRP breakdown →