ACY3

Across TCGA cell cohorts, ACY3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ACY3-associated genes across cancer lineages are HSFY2, TBATA, and FAM47A. Each is linked with ACY3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACY3-to-partner and partner-to-ACY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY2 grouped by ACY3-low versus ACY3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACY3→partner) and Y-score (partner→ACY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY2 →	+0.023	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.184	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	FAM47A →	+0.051	+3.734	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HSFY2 by ACY3 expression — LARGE_INTESTINE

Explore this box plot interactively →