ACTR3B

Across TCGA patient cohorts, ACTR3B mutation is significantly associated with the RNA expression of many other genes, with 4,325 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTR3B-associated genes across cancer lineages are SDHDP4, RNU2-53P, and RN7SL478P. Each is linked with ACTR3B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTR3B-to-partner and partner-to-ACTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SDHDP4 grouped by ACTR3B-low versus ACTR3B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTR3B→partner) and Y-score (partner→ACTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SDHDP4 →	+0.119	+4.730	<.001	<.001	3	2
LIHC	RNU2-53P →	+0.413	+6.676	<.001	<.001	3	2
UCEC	RN7SL478P →	+0.211	+2.091	<.001	.001	3	2
BRCA	HMGB3P23 →	+0.064	+5.054	<.001	.003	3	2
LUAD	KRTAP10-6 →	+0.070	+5.473	<.001	<.001	3	2
LUAD	UBE2Q2P11 →	+0.414	+4.821	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,325 associations by consensus.

SDHDP4 by ACTR3B expression — SKCM

Explore this box plot interactively →