ACTL7B

Across TCGA cell cohorts, ACTL7B mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ACTL7B-associated genes across cancer lineages are H4C6, ADIG, and TMEM95. Each is linked with ACTL7B in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL7B-to-partner and partner-to-ACTL7B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C6 grouped by ACTL7B-low versus ACTL7B-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL7B→partner) and Y-score (partner→ACTL7B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	H4C6 →	+0.387	+5.029	<.001	.006	3	2
BLOOD_Leukemia	ADIG →	+0.018	+4.984	<.001	.002	3	1
BLOOD_Leukemia	TMEM95 →	+0.022	+4.269	<.001	.002	3	1
BLOOD_Leukemia	VSIG10L2 →	+0.115	+3.944	.004	.006	3	1
LUNG_SCLC	PRAC1 →	+2.537	+5.029	.001	.006	3	1
LUNG_SCLC	URAD →	+0.044	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

H4C6 by ACTL7B expression — LUNG_SCLC

Explore this box plot interactively →