ACTL7B

Across TCGA pan-cancer cohorts, ACTL7B RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ACTL7B data layer compared with 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ACTL7B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ACTL7B expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

COAD, SCLC, and CHOL are the cancer types where ACTL7B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.776	0.884	.004	73	view →
SCLC	DFS	Quartile	III,IV	0.838	0.404	.004	65	view →
CHOL	OS	Tertile	All	0.538	0.867	.010	49	view →
LIHC	OS	Quartile	III,IV	0.223	0.684	<.001	45	view →
BRCA	DFS	Tertile	III,IV	0.746	0.421	.004	40	view →
MESO	OS	Tertile	IV	0.115	0.671	<.001	30	view →
STAD	OS	Tertile	III,IV	0.641	0.329	.011	21	view →
BLCA	DFS	Median	IV	0.132	0.260	.009	13	view →
LUSC	DFS	Tertile	III,IV	0.200	0.752	.042	13	view →
UVM	OS	Tertile	III,IV	0.221	0.798	.021	12	view →
KIRP	OS	Median	IV	0.043	0.523	.020	12	view →
ACC	OS	Tertile	All	0.422	0.818	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ACTL7B–COAD (OS)

Open the COAD breakdown →