ACTL6A

Across TCGA patient cohorts, ACTL6A mutation is significantly associated with the RNA expression of many other genes, with 835 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL6A-associated genes across cancer lineages are TXNL4AP1, CALM1P1, and RAB5CP2. Each is linked with ACTL6A in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTL6A-to-partner and partner-to-ACTL6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL4AP1 grouped by ACTL6A-low versus ACTL6A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL6A→partner) and Y-score (partner→ACTL6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TXNL4AP1 →	+0.228	+3.951	.001	.005	3	3
UCEC	CALM1P1 →	+0.293	+2.206	<.001	.004	3	3
UCEC	RAB5CP2 →	+0.256	+2.739	<.001	.001	3	3
BLCA	RPSAP65 →	+0.119	+3.629	<.001	.002	3	2
BLCA	SFPQP1 →	+0.022	+3.914	.004	.002	3	2
UCEC	PTP4A1P7 →	+0.205	+2.031	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 835 associations by consensus.

TXNL4AP1 by ACTL6A expression — COAD

Explore this box plot interactively →