ACTL10

Across TCGA patient cohorts, ACTL10 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTL10-associated genes across cancer lineages are LINC00353, VN2R9P, and RN7SL414P. Each is linked with ACTL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACTL10-to-partner and partner-to-ACTL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00353 grouped by ACTL10-low versus ACTL10-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTL10→partner) and Y-score (partner→ACTL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC00353 →	+0.224	+6.569	<.001	.001	3	1
CESC	VN2R9P →	+0.038	+5.201	.007	.007	3	1
CESC	RN7SL414P →	+0.119	+5.103	.001	.008	3	1
CESC	RPL32P30 →	+0.220	+5.010	.003	.009	3	1
CESC	MIR4674 →	+0.499	+5.103	<.001	.008	3	1
CESC	ATP6V1E1P2 →	+0.110	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

LINC00353 by ACTL10 expression — CESC

Explore this box plot interactively →