ACTL10

Across TCGA pan-cancer cohorts, ACTL10 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ACTL10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ACTL10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACTL10 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where ACTL10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACTL10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.702	<.001	10	view →
LIHC	All	II,III,IV	+0.572	<.001	8	view →
KICH	Male	II,III,IV	−0.923	<.001	7	view →
STAD	Male	All	+0.968	<.001	6	view →
BRCA	All	III,IV	+0.894	<.001	6	view →
CHOL	Female	All	+1.330	<.001	5	view →
LUAD	Female	III,IV	+1.108	<.001	5	view →
KIRP	All	All	+0.471	.007	4	view →
READ	All	All	+1.065	.001	3	view →
ESCA	All	All	+0.772	.028	3	view →
LUSC	All	All	+0.353	.011	3	view →
PRAD	All	All	+0.476	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ACTL10–COAD

Open the COAD breakdown →