Across TCGA patient cohorts, ACTG1 mutation is significantly associated with the RNA expression of many other genes, with 774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACTG1-associated genes across cancer lineages are MRPS36P2, OR5BD1P, and MIR4287. Each is linked with ACTG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACTG1-to-partner and partner-to-ACTG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACTG1→partner) and Y-score (partner→ACTG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	MRPS36P2 →	+0.193	+6.096	<.001	.002	3	3
LUAD	OR5BD1P →	+0.062	+5.523	<.001	.001	3	3
UCEC	MIR4287 →	+0.342	+4.660	<.001	<.001	3	3
UCEC	MIR6504 →	+0.368	+3.352	<.001	.004	3	2
CESC	SNRPGP6 →	+0.151	+5.252	<.001	.002	3	2
CESC	RN7SKP264 →	+0.121	+4.345	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 774 associations by consensus.

Exploration

ACTG1 survival (RNA) · tumor vs normal (RNA) · all ACTG1 data types