ACSL4

Across TCGA patient cohorts, ACSL4 protein abundance is significantly associated with the RNA expression of many other genes, with 19,862 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACSL4-associated genes across cancer lineages are ACSL5, CSF2RB, and SIRPB1. Each is linked with ACSL4 in more than 6 cancer types. Because this analysis shows association rather than direction, both ACSL4-to-partner and partner-to-ACSL4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACSL4 versus ACSL5 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL4→partner) and Y-score (partner→ACSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACSL5 →	+1.593	+0.717	<.001	<.001	3	7
LSCC	CSF2RB →	+1.074	+0.436	<.001	<.001	3	6
GBM	SIRPB1 →	+0.623	+0.348	<.001	<.001	3	6
GBM	LILRB2 →	+1.003	+0.374	<.001	<.001	3	6
LSCC	SCIMP →	+0.721	+0.355	<.001	<.001	3	6
BRCA	CD7 →	+0.973	+0.401	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,862 associations by consensus.

ACSL4 vs ACSL5 — UCEC

Explore this scatter interactively →