ACSL4

Across TCGA patient cohorts, ACSL4 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSL4-associated genes across cancer lineages are eIF4E, ASNS, and ERK2. Each is linked with ACSL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSL4-to-partner and partner-to-ACSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ACSL4-low versus ACSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL4→partner) and Y-score (partner→ACSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.153	+1.523	.010	.006	3	3
UCEC	ASNS →	+0.397	+1.584	<.001	.007	3	3
UCEC	ERK2 →	+0.132	+1.678	.014	.019	3	2
UCEC	Akt_pS473 →	+0.535	+1.353	.007	.013	3	2
UCEC	PCNA →	+0.161	+1.273	.007	.007	3	2
UCEC	ATM →	-0.387	-2.074	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

eIF4E by ACSL4 expression — UCEC

Explore this box plot interactively →