ACSL4

Across TCGA cell cohorts, ACSL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,449 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ACSL4-associated GO terms across cancer lineages are Negative regulation of icosanoid secretion, Positive regulation of ferroptosis, and Negative regulation of fatty acid transport. Each is linked with ACSL4 in more than 18 cancer types. Because this analysis shows association rather than direction, both ACSL4-to-partner and partner-to-ACSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of icosanoid secretion grouped by ACSL4-low versus ACSL4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL4→partner) and Y-score (partner→ACSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of icosanoid secretion →	+1.766	+3.212	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Positive regulation of ferroptosis →	+0.175	+1.494	.002	.003	3	17
LUNG_NSCLC_LUSC	Negative regulation of fatty acid transport →	+0.264	+2.072	<.001	<.001	3	15
BREAST	Regulation of protein localization to early endosome →	+0.176	+2.504	<.001	<.001	3	13
BREAST	Positive regulation of protein localization to early endosome →	+0.176	+2.504	<.001	<.001	3	13
BONE	Positive regulation of cell-substrate junction organization →	+0.152	+1.236	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,449 associations by consensus.

Negative regulation of icosanoid secretion by ACSL4 expression — BREAST

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