ACSL4

Across TCGA cell cohorts, ACSL4 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ACSL4-associated genes across cancer lineages are FSHB, FAM205A, and OR52B2. Each is linked with ACSL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACSL4-to-partner and partner-to-ACSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSHB grouped by ACSL4-low versus ACSL4-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL4→partner) and Y-score (partner→ACSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FSHB →	+0.032	+5.321	<.001	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.019	+3.766	.001	.004	3	1
BLOOD_Lymphoma	OR52B2 →	+0.039	+4.714	<.001	.002	3	1
BLOOD_Leukemia	TEX43 →	+0.105	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FSHB by ACSL4 expression — CNS

Explore this box plot interactively →