ACOT7

Across TCGA cell cohorts, ACOT7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible ACOT7-associated genes across cancer lineages are FAM47C, IZUMO1R, and OR51L1. Each is linked with ACOT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT7-to-partner and partner-to-ACOT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM47C grouped by ACOT7-low versus ACOT7-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT7→partner) and Y-score (partner→ACOT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM47C →	+0.014	+4.017	<.001	.007	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR51L1 →	+0.038	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	HTR1A →	+0.012	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	IZUMO3 →	+0.043	+4.947	<.001	.001	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FAM47C by ACOT7 expression — OESOPHAGUS

Explore this box plot interactively →