ACOT7

Across TCGA pan-cancer cohorts, ACOT7 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ACOT7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACOT7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACOT7 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, THCA, and KIRC are the cancer types where ACOT7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACOT7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.630	<.001	12	view →
THCA	Male	III,IV	+1.528	<.001	11	view →
KIRC	All	II,III,IV	+1.056	<.001	11	view →
STAD	All	II,III,IV	+1.202	<.001	9	view →
LUSC	Male	II,III,IV	+1.406	<.001	8	view →
LIHC	Female	II,III,IV	+1.109	<.001	7	view →
COAD	Female	All	+0.758	<.001	7	view →
BRCA	All	III,IV	+1.195	<.001	6	view →
BLCA	All	All	+0.903	.003	6	view →
UCEC	All	All	+0.762	<.001	6	view →
KICH	All	All	−1.149	<.001	4	view →
KIRP	All	All	−1.046	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ACOT7–HNSC

Open the HNSC breakdown →