ACAP3

Across TCGA cell cohorts, ACAP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,476 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACAP3-associated GO terms across cancer lineages are Regulation of transcription of nucleolar large rRNA by RNA polymerase I, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with ACAP3 in more than 17 cancer types. Because this analysis shows association rather than direction, both ACAP3-to-partner and partner-to-ACAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of transcription of nucleolar large rRNA by RNA polymerase I grouped by ACAP3-low versus ACAP3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP3→partner) and Y-score (partner→ACAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.252	+1.955	<.001	<.001	3	18
OESOPHAGUS	Symbiont-mediated disruption of host cellular anatomical structure →	+0.194	+1.497	<.001	.002	3	16
OESOPHAGUS	Symbiont-mediated disruption of host anatomical structure →	+0.194	+1.497	<.001	.002	3	16
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.140	+1.476	<.001	<.001	3	16
BONE	Negative regulation of translational initiation →	+0.140	+1.339	<.001	.001	3	15
BONE	Positive regulation of DNA metabolic process →	+0.076	+1.209	.002	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,476 associations by consensus.

Regulation of transcription of nucleolar large rRNA by RNA polymerase I by ACAP3 expression — BONE

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