ACAP3

Across TCGA pan-cancer cohorts, ACAP3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ACAP3 data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ACAP3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACAP3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRP show a favorable association.

KIRC, ACC, and HNSC are the cancer types where ACAP3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.348	0.621	.001	128	view →
ACC	DFS	Quartile	All	0.225	0.670	<.001	90	view →
HNSC	OS	Tertile	All	0.835	0.694	.001	60	view →
KIRP	DFS	Median	II,III,IV	0.928	0.176	<.001	57	view →
BRCA	DFS	Tertile	All	0.928	0.969	<.001	47	view →
STAD	DFS	Tertile	III,IV	0.258	0.567	.006	43	view →
LIHC	DFS	Median	All	0.463	0.617	<.001	41	view →
PRAD	DFS	Median	All	0.823	0.938	<.001	32	view →
CHOL	DFS	Tertile	All	0.878	0.136	.001	29	view →
SKCM	DFS	Quartile	All	0.654	0.840	<.001	20	view →
PAAD	OS	Tertile	All	0.510	0.233	.007	18	view →
LUAD	OS	Tertile	II,III,IV	0.692	0.469	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ACAP3–KIRC (DFS)

Open the KIRC breakdown →