ACAP3

Across TCGA pan-cancer cohorts, ACAP3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ACAP3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ACAP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACAP3 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, LIHC, and KIRC are the cancer types where ACAP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACAP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.428	<.001	10	view →
LIHC	Female	II,III,IV	+1.425	<.001	9	view →
KIRC	Male	IV	+0.621	<.001	9	view →
KIRP	All	All	+0.488	.001	9	view →
KICH	Female	All	−0.883	<.001	6	view →
LUAD	All	II,III,IV	+0.534	<.001	6	view →
CHOL	All	All	+1.326	<.001	5	view →
LUSC	Male	All	+0.582	<.001	4	view →
BRCA	All	All	+0.237	.004	4	view →
THCA	All	All	+0.200	.006	2	view →
READ	All	All	+0.476	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ACAP3–COAD

Open the COAD breakdown →