ACAP3

Across TCGA cell cohorts, ACAP3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACAP3-associated genes across cancer lineages are PHOX2B, NPFFR1, and KRT6C. Each is linked with ACAP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAP3-to-partner and partner-to-ACAP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHOX2B grouped by ACAP3-low versus ACAP3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAP3→partner) and Y-score (partner→ACAP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PHOX2B →	+0.017	+3.365	<.001	.005	3	1
BLOOD_Leukemia	NPFFR1 →	+0.011	+3.359	<.001	.002	3	1
BLOOD_Leukemia	KRT6C →	+0.019	+3.359	<.001	.002	3	1
BLOOD_Leukemia	ARL13A →	+0.082	+3.337	<.001	.007	3	1
BLOOD_Leukemia	SMIM23 →	+0.012	+4.247	<.001	.004	3	1
BLOOD_Leukemia	MORN5 →	+0.238	+3.177	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PHOX2B by ACAP3 expression — BLOOD_Leukemia

Explore this box plot interactively →