ACACB

Across TCGA patient cohorts, ACACB mutation is significantly associated with the RNA expression of many other genes, with 8,124 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACACB-associated genes across cancer lineages are RAD54L, FAM72B, and STIL. Each is linked with ACACB in more than 6 cancer types. Because this analysis shows association rather than direction, both ACACB-to-partner and partner-to-ACACB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD54L grouped by ACACB-low versus ACACB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACB→partner) and Y-score (partner→ACACB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RAD54L →	+0.937	+3.468	<.001	.002	3	7
LUAD	FAM72B →	+0.561	+3.339	<.001	.005	3	7
COAD	STIL →	+0.407	+3.183	.007	.009	3	7
STAD	CDC25A →	+0.834	+3.334	<.001	.005	3	6
STAD	DDIAS →	+0.595	+3.186	.009	.009	3	6
UCEC	CHAF1A →	+0.704	+2.289	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,124 associations by consensus.

RAD54L by ACACB expression — LUAD

Explore this box plot interactively →