ACACB

Across TCGA pan-cancer cohorts, ACACB RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ACACB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ACACB RNA is repressed in tumor relative to normal tissue. In most cancer types ACACB is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where ACACB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACACB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−2.502	<.001	11	view →
COAD	All	III,IV	−1.416	<.001	11	view →
LUAD	Female	II,III,IV	−1.412	<.001	9	view →
KIRC	Male	II,III,IV	−0.827	<.001	9	view →
BLCA	Male	IV	−3.505	<.001	8	view →
LUSC	All	III,IV	−1.783	<.001	8	view →
HNSC	All	IV	−1.224	<.001	8	view →
LIHC	All	II,III,IV	−0.984	<.001	8	view →
READ	All	All	−1.691	<.001	7	view →
BRCA	All	All	−2.995	<.001	6	view →
UCEC	All	All	−2.086	<.001	6	view →
KIRP	Male	All	−1.459	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ACACB–THCA

Open the THCA breakdown →