ACACB

Across TCGA pan-cancer cohorts, ACACB RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ACACB data layer compared with 11 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ACACB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ACACB expression acts as an unfavorable survival marker, although some lineages such as SCLC and HNSC show a favorable association.

UVM, UCEC, and SCLC are the cancer types where ACACB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.431	0.973	<.001	134	view →
UCEC	OS	Median	All	0.598	0.746	<.001	90	view →
SCLC	OS	Quartile	All	0.671	0.283	.002	89	view →
HNSC	DFS	Tertile	IV	0.732	0.537	.001	71	view →
PAAD	OS	Tertile	All	0.551	0.281	<.001	59	view →
ACC	DFS	Tertile	All	0.304	0.720	<.001	58	view →
MESO	OS	Tertile	All	0.677	0.378	<.001	53	view →
LGG	DFS	Median	All	0.653	0.816	<.001	51	view →
KIRP	DFS	Tertile	All	0.958	0.852	.007	46	view →
KIRC	OS	Tertile	All	0.724	0.572	.001	36	view →
BRCA	OS	Median	III,IV	0.669	0.399	<.001	32	view →
COAD	OS	Tertile	All	0.473	0.707	.001	25	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ACACB–UVM (OS)

Open the UVM breakdown →