ACACB

Across TCGA patient cohorts, ACACB mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACACB-associated genes across cancer lineages are Cyclin-B1, eIF4E, and FoxM1. Each is linked with ACACB in more than 4 cancer types. Because this analysis shows association rather than direction, both ACACB-to-partner and partner-to-ACACB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ACACB-low versus ACACB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACACB→partner) and Y-score (partner→ACACB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.601	+1.772	<.001	<.001	3	5
STAD	eIF4E →	+0.187	+2.584	.013	.010	3	4
STAD	FoxM1 →	+0.374	+3.169	<.001	.017	3	3
STAD	FASN →	+0.446	+3.185	.010	.009	3	3
STAD	FOXO3a_pS318_S321 →	-0.248	-2.563	.001	.010	3	3
STAD	Notch1 →	+0.160	+1.895	.023	.029	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

Cyclin-B1 by ACACB expression — UCEC

Explore this box plot interactively →