ACAA1

Across TCGA patient cohorts, ACAA1 mutation is significantly associated with the RNA expression of many other genes, with 589 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACAA1-associated genes across cancer lineages are MIR6508, HIGD1AP2, and LINC00458. Each is linked with ACAA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACAA1-to-partner and partner-to-ACAA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6508 grouped by ACAA1-low versus ACAA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACAA1→partner) and Y-score (partner→ACAA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6508 →	+0.351	+2.675	<.001	.007	3	2
SKCM	HIGD1AP2 →	+0.060	+4.212	.001	.007	3	2
UCEC	LINC00458 →	+0.330	+2.653	<.001	.001	3	2
KIRP	DEFB135 →	+0.157	+5.770	<.001	.003	3	1
KIRP	PEX12P1 →	+0.055	+5.060	<.001	.008	3	1
KIRP	GYG2-AS1 →	+0.075	+5.159	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 589 associations by consensus.

MIR6508 by ACAA1 expression — UCEC

Explore this box plot interactively →