ACAA1

Across TCGA pan-cancer cohorts, ACAA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ACAA1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ACAA1 RNA is repressed in tumor relative to normal tissue. In most cancer types ACAA1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and HNSC are the cancer types where ACAA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACAA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	−2.144	<.001	11	view →
KIRC	Male	All	−1.215	<.001	11	view →
HNSC	All	III,IV	−0.541	<.001	11	view →
KICH	Female	II,III,IV	−1.810	<.001	10	view →
COAD	Female	III,IV	−1.186	<.001	10	view →
LIHC	All	II,III,IV	−1.149	<.001	8	view →
LUAD	Male	II,III,IV	−0.635	<.001	8	view →
LUSC	Female	All	−0.933	<.001	6	view →
CHOL	Female	All	−2.736	<.001	5	view →
UCEC	All	III,IV	+0.437	.004	4	view →
BRCA	All	II,III,IV	−0.211	.030	2	view →
THCA	All	All	+0.162	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ACAA1–KIRP

Open the KIRP breakdown →