ABRA

Across TCGA cell cohorts, ABRA mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ABRA-associated genes across cancer lineages are SSTR4, ACP4, and CHRNB3. Each is linked with ABRA in more than 1 cancer types. Because this analysis shows association rather than direction, both ABRA-to-partner and partner-to-ABRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSTR4 grouped by ABRA-low versus ABRA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABRA→partner) and Y-score (partner→ABRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SSTR4 →	+0.034	+3.084	<.001	.002	3	1
SKIN	ACP4 →	+0.015	+2.933	<.001	.003	3	1
SKIN	CHRNB3 →	+0.006	+2.882	<.001	.005	3	1
SKIN	TFDP3 →	+0.219	+3.839	.005	.001	3	1
SKIN	H1-7 →	+0.047	+3.141	<.001	.002	3	1
SKIN	RNF212B →	+0.054	+2.716	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SSTR4 by ABRA expression — SKIN

Explore this box plot interactively →