ABRA

Across TCGA pan-cancer cohorts, ABRA RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ABRA data layer compared with 4 for mutation status.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher ABRA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABRA expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

DLBC, BLCA, and UVM are the cancer types where ABRA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Tertile	II,III,IV	0.166	0.824	.003	40	view →
BLCA	DFS	Median	All	0.700	0.476	.003	34	view →
UVM	DFS	Tertile	All	0.383	0.630	.006	33	view →
LUAD	OS	Quartile	All	0.864	0.748	.006	32	view →
ESCA	DFS	Quartile	All	0.284	1.000	.008	24	view →
HNSC	OS	Median	III,IV	0.655	0.791	.001	22	view →
STAD	DFS	Tertile	IV	0.706	0.247	.036	19	view →
BRCA	OS	Tertile	III,IV	0.711	0.488	.008	12	view →
KIRP	DFS	Median	II,III,IV	0.902	0.345	.015	11	view →
ACC	OS	Tertile	All	0.752	0.901	.017	10	view →
SCLC	OS	Tertile	IV	0.164	0.647	.017	9	view →
LUSC	DFS	Median	III,IV	0.309	0.839	.001	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ABRA–DLBC (OS)

Open the DLBC breakdown →