ABHD8

Across TCGA patient cohorts, ABHD8 mutation is significantly associated with the RNA expression of many other genes, with 1,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD8-associated genes across cancer lineages are UQCRBP3, LINC02465, and LDHAP1. Each is linked with ABHD8 in more than 2 cancer types. Because this analysis shows association rather than direction, both ABHD8-to-partner and partner-to-ABHD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRBP3 grouped by ABHD8-low versus ABHD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD8→partner) and Y-score (partner→ABHD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRBP3 →	+0.192	+2.911	<.001	.003	3	3
CESC	LINC02465 →	+0.051	+3.455	<.001	.002	3	2
CESC	LDHAP1 →	+0.094	+3.652	<.001	.005	3	2
CESC	NF1P10 →	+0.206	+4.247	<.001	.007	3	2
SKCM	RBM17P2 →	+0.037	+4.208	<.001	.003	3	2
HNSC	SNORD111B →	+0.570	+4.025	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,058 associations by consensus.

UQCRBP3 by ABHD8 expression — UCEC

Explore this box plot interactively →