ABHD4

Across TCGA patient cohorts, ABHD4 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD4-associated genes across cancer lineages are eEF2K, EGFR_pY1068, and eIF4G. Each is linked with ABHD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD4-to-partner and partner-to-ABHD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2K grouped by ABHD4-low versus ABHD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD4→partner) and Y-score (partner→ABHD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2K →	+0.296	+3.321	.016	.010	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.321	.003	.005	3	1
UCEC	eIF4G →	+0.221	+1.700	.043	.042	3	1
UCEC	ERK2 →	+0.189	+2.000	.005	.009	3	1
UCEC	Gab2 →	+0.291	+1.362	.020	.037	3	1
UCEC	ACC1 →	+0.270	+2.335	.035	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2K by ABHD4 expression — UCEC

Explore this box plot interactively →