ABHD4

Across TCGA pan-cancer cohorts, ABHD4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ABHD4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ABHD4 RNA is repressed in tumor relative to normal tissue. In most cancer types ABHD4 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where ABHD4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABHD4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.175	<.001	11	view →
KIRC	Male	II,III,IV	−0.700	<.001	11	view →
LIHC	Female	II,III,IV	+1.574	<.001	9	view →
KIRP	All	II,III,IV	+0.775	.001	6	view →
CHOL	All	All	+2.126	<.001	5	view →
LUSC	All	All	+0.518	<.001	5	view →
COAD	Female	All	−0.479	.004	4	view →
BLCA	Female	III,IV	+0.978	.009	3	view →
LUAD	All	II,III,IV	+0.327	.026	3	view →
PRAD	All	All	−0.452	<.001	2	view →
HNSC	All	All	+0.386	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ABHD4–KICH

Open the KICH breakdown →