ABHD4

Across TCGA pan-cancer cohorts, ABHD4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ABHD4 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ABHD4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABHD4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and LAML show a favorable association.

LUAD, LIHC, and BLCA are the cancer types where ABHD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.735	0.846	<.001	99	view →
LIHC	DFS	Median	All	0.468	0.612	<.001	83	view →
BLCA	OS	Median	II,III,IV	0.539	0.682	.002	62	view →
ACC	DFS	Median	All	0.262	0.625	.002	23	view →
KIRP	OS	Median	All	0.824	0.937	.002	19	view →
BRCA	DFS	Tertile	III,IV	0.952	0.805	.001	18	view →
LAML	DFS	Median	All	0.698	0.461	.012	18	view →
PAAD	OS	Tertile	All	0.227	0.566	.010	15	view →
HNSC	OS	Quartile	All	0.195	0.566	.001	15	view →
READ	OS	Tertile	All	0.539	0.831	.009	14	view →
LGG	DFS	Tertile	All	0.889	0.815	.007	12	view →
COAD	OS	Quartile	All	0.435	0.708	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ABHD4–LUAD (DFS)

Open the LUAD breakdown →