ABHD12B

Across TCGA patient cohorts, ABHD12B mutation is significantly associated with the RNA expression of many other genes, with 145 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD12B-associated genes across cancer lineages are POLR2DP2, RNU6-1213P, and RNU6-225P. Each is linked with ABHD12B in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD12B-to-partner and partner-to-ABHD12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLR2DP2 grouped by ABHD12B-low versus ABHD12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD12B→partner) and Y-score (partner→ABHD12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLR2DP2 →	+0.113	+2.675	.002	.007	3	2
UCEC	RNU6-1213P →	+0.376	+4.707	<.001	<.001	3	2
SKCM	RNU6-225P →	+0.399	+5.970	<.001	.002	3	1
SKCM	RNA5SP158 →	+0.516	+5.436	<.001	.005	3	1
SKCM	RN7SKP3 →	+0.173	+5.771	<.001	.003	3	1
CESC	FLYWCH1P1 →	+0.023	+5.103	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 145 associations by consensus.

POLR2DP2 by ABHD12B expression — UCEC

Explore this box plot interactively →