ABHD12B

Across TCGA pan-cancer cohorts, ABHD12B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ABHD12B data layer compared with 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ABHD12B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABHD12B expression acts as an unfavorable survival marker, although some lineages such as UCEC and KIRP show a favorable association.

COAD, UCEC, and HNSC are the cancer types where ABHD12B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.259	0.562	.003	53	view →
UCEC	DFS	Median	All	0.929	0.863	.004	44	view →
HNSC	DFS	Tertile	All	0.322	0.468	.007	40	view →
LGG	OS	Tertile	All	0.747	0.870	.001	35	view →
KIRP	DFS	Median	II,III,IV	0.905	0.334	.009	25	view →
MESO	OS	Median	All	0.649	0.431	.001	25	view →
BRCA	DFS	Quartile	III,IV	0.950	0.824	.006	23	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	20	view →
SARC	DFS	Quartile	All	0.478	0.728	.012	12	view →
LAML	DFS	Tertile	All	0.519	0.354	.023	12	view →
OV	DFS	Median	II,III,IV	0.125	0.188	.026	10	view →
UVM	OS	Quartile	II,III,IV	0.557	0.931	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ABHD12B–COAD (DFS)

Open the COAD breakdown →