ABHD12B

Across TCGA pan-cancer cohorts, ABHD12B RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ABHD12B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ABHD12B RNA is repressed in tumor relative to normal tissue. In most cancer types ABHD12B is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and KIRC are the cancer types where ABHD12B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABHD12B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.370	<.001	8	view →
LUAD	All	All	−0.320	<.001	7	view →
KIRC	All	All	+0.157	<.001	5	view →
LIHC	All	All	+0.260	.002	4	view →
HNSC	Male	III,IV	+0.266	.009	2	view →
PRAD	All	All	−0.115	<.001	2	view →
KIRP	All	All	−0.097	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ABHD12B–KICH

Open the KICH breakdown →