ABHD12B

Across TCGA patient cohorts, ABHD12B mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABHD12B-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and PRDX1. Each is linked with ABHD12B in more than 1 cancer types. Because this analysis shows association rather than direction, both ABHD12B-to-partner and partner-to-ABHD12B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ABHD12B-low versus ABHD12B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABHD12B→partner) and Y-score (partner→ABHD12B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.189	-3.000	.020	.036	3	1
UCEC	Ku80 →	+0.291	+3.009	.010	.019	3	1
UCEC	PRDX1 →	+0.214	+3.169	.032	.019	3	1
UCEC	Src_pY527 →	-0.489	-2.990	.018	.036	3	1
UCEC	STAT3_pY705 →	-0.602	-3.311	<.001	.010	3	1
UCEC	ATM →	-0.619	-2.986	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK_pT183_Y185 by ABHD12B expression — UCEC

Explore this box plot interactively →