ABCG8

Across TCGA patient cohorts, ABCG8 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCG8-associated genes across cancer lineages are EGFR_pY1068, MAPK_pT202_Y204, and 4E-BP1_pT37_T46. Each is linked with ABCG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG8-to-partner and partner-to-ABCG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ABCG8-low versus ABCG8-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG8→partner) and Y-score (partner→ABCG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	EGFR_pY1068 →	-0.347	-1.798	.037	.026	3	2
LUSC	MAPK_pT202_Y204 →	-0.325	-2.312	.015	.006	3	2
UCEC	4E-BP1_pT37_T46 →	-0.295	-1.794	.020	.024	3	2
SKCM	4E-BP1 →	+0.424	+3.000	.003	.034	3	2
SKCM	STAT3_pY705 →	-0.264	-2.459	.042	.020	3	2
SKCM	DJ-1 →	+0.240	+2.476	.005	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

EGFR_pY1068 by ABCG8 expression — LUSC

Explore this box plot interactively →