ABCG8

Across TCGA pan-cancer cohorts, ABCG8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ABCG8’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ABCG8 RNA is repressed in tumor relative to normal tissue. In most cancer types ABCG8 is over-expressed in tumor, although a few such as LIHC and KIRC show the opposite, repressed pattern.

LIHC, KIRC, and CHOL are the cancer types where ABCG8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ABCG8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	II,III,IV	−1.319	.002	6	view →
KIRC	Male	All	−0.570	<.001	6	view →
CHOL	Female	All	−5.770	<.001	5	view →
LUSC	All	All	+0.165	.001	5	view →
BRCA	All	All	−0.149	<.001	4	view →
KICH	Male	IV	−0.673	.018	3	view →
HNSC	All	All	+0.093	.042	3	view →
BLCA	All	All	+0.087	.028	2	view →
PRAD	All	All	+0.029	.001	2	view →
KIRP	Male	All	−0.391	.031	1	view →
LUAD	All	All	+0.046	.037	1	view →
THCA	All	All	−0.010	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ABCG8–LIHC

Open the LIHC breakdown →