ABCG8

Across TCGA pan-cancer cohorts, ABCG8 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ABCG8 data layer compared with 4 for mutation status.

The strongest signal is observed in cholangiocarcinoma (CHOL), where higher ABCG8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ABCG8 expression acts as an unfavorable survival marker, although some lineages such as MESO and BLCA show a favorable association.

CHOL, MESO, and BLCA are the cancer types where ABCG8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CHOL	OS	Median	II,III,IV	0.349	0.915	.001	43	view →
MESO	OS	Tertile	All	0.732	0.252	.008	39	view →
BLCA	OS	Tertile	III,IV	0.488	0.156	.004	39	view →
STAD	OS	Median	All	0.339	0.718	<.001	37	view →
SCLC	OS	Median	All	0.491	0.243	.006	30	view →
KIRC	DFS	Quartile	All	0.490	0.709	.001	30	view →
ACC	OS	Median	All	0.789	0.930	.016	28	view →
CESC	OS	Tertile	IV	0.837	0.106	.015	20	view →
ESCA	OS	Median	All	0.440	1.000	.008	18	view →
KIRP	OS	Median	II,III,IV	0.854	0.626	.007	18	view →
LUAD	OS	Tertile	II,III,IV	0.617	0.801	.002	18	view →
LIHC	OS	Median	All	0.776	0.617	.002	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ABCG8–CHOL (OS)

Open the CHOL breakdown →