ABCG8

Across TCGA cell cohorts, ABCG8 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCG8-associated genes across cancer lineages are FAM71C, GZMK, and INSM2. Each is linked with ABCG8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCG8-to-partner and partner-to-ABCG8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71C grouped by ABCG8-low versus ABCG8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCG8→partner) and Y-score (partner→ABCG8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FAM71C →	+0.017	+4.095	<.001	.009	3	1
BLOOD_Leukemia	GZMK →	+0.484	+4.037	.001	.004	3	1
BLOOD_Leukemia	INSM2 →	+0.155	+3.769	.004	.008	3	1
BLOOD_Leukemia	RXFP3 →	+0.010	+3.874	<.001	.005	3	1
BLOOD_Leukemia	LRIT2 →	+0.101	+4.362	.001	.002	3	1
BLOOD_Leukemia	TSSK1B →	+0.017	+5.289	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FAM71C by ABCG8 expression — SKIN

Explore this box plot interactively →