ABCD4

Across TCGA patient cohorts, ABCD4 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCD4-associated genes across cancer lineages are PDCD4, 14-3-3_beta, and EGFR_pY1068. Each is linked with ABCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD4-to-partner and partner-to-ABCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by ABCD4-low versus ABCD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD4→partner) and Y-score (partner→ABCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.663	-3.160	.002	.019	3	2
UCEC	14-3-3_beta →	-0.109	-2.973	.020	.035	3	1
UCEC	EGFR_pY1068 →	-0.363	-3.700	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.189	-3.169	<.001	.019	3	1
UCEC	FoxM1 →	+0.302	+2.584	.012	.011	3	1
UCEC	HER3 →	+0.456	+2.820	<.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

PDCD4 by ABCD4 expression — UCEC

Explore this box plot interactively →