ABCD1

Across TCGA cell cohorts, ABCD1 mutation is significantly associated with the RNA expression of many other genes, with 115 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ABCD1-associated genes across cancer lineages are BHLHE23, NKX2-6, and VSX1. Each is linked with ABCD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ABCD1-to-partner and partner-to-ABCD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BHLHE23 grouped by ABCD1-low versus ABCD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCD1→partner) and Y-score (partner→ABCD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BHLHE23 →	+1.181	+2.954	<.001	.005	3	2
LUNG_NSCLC_LUAD	NKX2-6 →	+1.222	+3.544	<.001	.009	3	2
BLOOD_Leukemia	VSX1 →	+0.275	+3.083	<.001	.003	3	1
BLOOD_Leukemia	SLC32A1 →	+0.806	+2.638	<.001	.009	3	1
BLOOD_Leukemia	FAM149A →	+1.787	+3.309	<.001	.006	3	1
BLOOD_Leukemia	PROX1 →	+0.628	+3.266	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 115 associations by consensus.

BHLHE23 by ABCD1 expression — BLOOD_Leukemia

Explore this box plot interactively →