ABCD1

Across TCGA pan-cancer cohorts, ABCD1 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated ABCD1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ABCD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ABCD1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and SARC show a favorable association.

BRCA, LGG, and LIHC are the cancer types where ABCD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.929	0.967	<.001	100	view →
LGG	DFS	Median	All	0.295	0.496	<.001	49	view →
LIHC	DFS	Quartile	All	0.281	0.619	<.001	49	view →
LUAD	DFS	Tertile	All	0.732	0.851	<.001	47	view →
UCEC	OS	Quartile	All	0.811	0.926	.001	46	view →
KIRC	DFS	Tertile	All	0.799	0.923	.001	40	view →
SCLC	DFS	Median	All	0.738	0.500	.003	38	view →
LAML	DFS	Quartile	All	0.285	0.625	<.001	34	view →
COAD	DFS	Median	II,III,IV	0.696	0.845	.002	30	view →
SARC	DFS	Quartile	All	0.627	0.384	<.001	29	view →
STAD	OS	Median	IV	0.564	0.192	.004	27	view →
CESC	OS	Quartile	IV	0.838	0.259	.008	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

ABCD1–BRCA (DFS)

Open the BRCA breakdown →