ABCC2

Across TCGA patient cohorts, ABCC2 mutation is significantly associated with the RNA expression of many other genes, with 4,443 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCC2-associated genes across cancer lineages are PPP2R2D, RNU6-13P, and ARHGAP19. Each is linked with ABCC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCC2-to-partner and partner-to-ABCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by ABCC2-low versus ABCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCC2→partner) and Y-score (partner→ABCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R2D →	+0.242	+1.243	<.001	<.001	3	4
COAD	RNU6-13P →	+0.387	+3.630	<.001	<.001	3	4
UCEC	ARHGAP19 →	+0.353	+1.348	<.001	.002	3	4
COAD	CCL8 →	+1.084	+2.700	<.001	.006	3	3
LUAD	HAUS8 →	+0.422	+3.819	.001	<.001	3	3
COAD	ATP6V1B2 →	+0.498	+2.906	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,443 associations by consensus.

PPP2R2D by ABCC2 expression — UCEC

Explore this box plot interactively →